Title : Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt.

Pub. Date : 2010 Feb

PMID : 19918798






3 Functional Relationships(s)
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Protein Name
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1 PTX/LPC combination acted by favoring p53 stabilization through a lowering in p-Akt levels and in ps166-MDM2, the phosphorylated-MDM2 form that enters the nucleus and induces p53 export and degradation. Paclitaxel MDM2 proto-oncogene Homo sapiens
2 PTX/LPC combination acted by favoring p53 stabilization through a lowering in p-Akt levels and in ps166-MDM2, the phosphorylated-MDM2 form that enters the nucleus and induces p53 export and degradation. Paclitaxel MDM2 proto-oncogene Homo sapiens
3 PTX/LPC treatment induced a weakness of Akt-MDM2-p53 complex and increased nuclear p53 levels. Paclitaxel MDM2 proto-oncogene Homo sapiens