Pub. Date : 2010 Jan
PMID : 19913321
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Pretreatment with sorafenib enhanced bortezomib-induced apoptotic cell death by restoring bortezomib"s ability to inactivate Akt in PLC/PRF/5 cells. | Sorafenib | heparan sulfate proteoglycan 2 | Homo sapiens |
| 2 | Notably, sorafenib with bortezomib increased PP2A activity in PLC/PRF/5 cells without altering protein levels of PP2A complex or the interaction between PP2A and Akt proteins. | Sorafenib | heparan sulfate proteoglycan 2 | Homo sapiens |
| 3 | Finally, sorafenib plus bortezomib significantly suppressed PLC/PRF/5 xenograft tumor growth, down-regulated P-Akt expression, and up-regulated PP2A activity. | Sorafenib | heparan sulfate proteoglycan 2 | Homo sapiens |