Pub. Date : 2010 Mar
PMID : 19913094
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Extracellular S1P activates specific G protein-coupled receptors while intracellular S1P can mobilize Ca2+ from thapsigargin-sensitive stores. | Thapsigargin | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 2 | Importantly, [Ca2+]i increases and Ca2+ mobilization induced by the SERCA inhibitor, thapsigargin, were augmented, indicating enhanced Ca2+ storage in S1P lyase-deficient MEFs. | Thapsigargin | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 3 | The area under the time course of thapsigargin-induced [Ca2+]i increases, reflecting overall Ca2+ release, was significantly increased by more than 50% in both rapidly and slowly responding S1P lyase-deficient cells. | Thapsigargin | sphingosine-1-phosphate receptor 1 | Mus musculus |