Title : Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation.

Pub. Date : 2009

PMID : 19906289






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Incubation with IL-1Ra, dexamethasone, or TNF inhibitors significantly decreased levels of all forms of MMP-3 (P < 0.05). Dexamethasone matrix metallopeptidase 3 Homo sapiens
2 Dexamethasone significantly decreased the ratio of active MMP-3 to total MMP-3 activity. Dexamethasone matrix metallopeptidase 3 Homo sapiens
3 Dexamethasone significantly decreased the ratio of active MMP-3 to total MMP-3 activity. Dexamethasone matrix metallopeptidase 3 Homo sapiens
4 Dexamethasone, IL-1-Ra and TNF inhibitor decreased active MMP-3, indicating that the clinical use of these drugs may affect the resorption of DH under certain conditions. Dexamethasone matrix metallopeptidase 3 Homo sapiens