Pub. Date : 2010 Jan
PMID : 19898263
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response. | Metformin | solute carrier family 22 member 1 | Homo sapiens |
| 2 | OBJECTIVE: Metformin is transported into the hepatocyte by organic cation transporter 1 (OCT1) and out of the hepatocyte by multidrug and toxin extrusion 1 (MATE1). | Metformin | solute carrier family 22 member 1 | Homo sapiens |
| 3 | OBJECTIVE: Metformin is transported into the hepatocyte by organic cation transporter 1 (OCT1) and out of the hepatocyte by multidrug and toxin extrusion 1 (MATE1). | Metformin | solute carrier family 22 member 1 | Homo sapiens |
| 4 | Recently, we discovered that polymorphisms rs622342 A>C in the SLC22A1 gene, coding for OCT1, and rs2289669 G>A in the SLC47A1 gene, coding for MATE1, are associated with the degree of glucose lowering by metformin. | Metformin | solute carrier family 22 member 1 | Homo sapiens |
| 5 | Recently, we discovered that polymorphisms rs622342 A>C in the SLC22A1 gene, coding for OCT1, and rs2289669 G>A in the SLC47A1 gene, coding for MATE1, are associated with the degree of glucose lowering by metformin. | Metformin | solute carrier family 22 member 1 | Homo sapiens |
| 6 | CONCLUSION: The effect of the MATE1 rs2289669 polymorphism on the glucose lowering effect of metformin is larger in incident users with the OCT1 rs622342 CC genotype than in incident users with the AA genotype. | Metformin | solute carrier family 22 member 1 | Homo sapiens |