Title : The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells.

Pub. Date : 2009 Dec

PMID : 19885570






1 Functional Relationships(s)
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1 The combination of safingol/irinotecan at 1:1 molar ratio was found to be additive in HT-29 cells (CI=0.94) and synergistic in LS-174T cells (CI=0.68), and resulted in concentration- and time-dependent down-regulation of p-PKC and p-MARCKS. Irinotecan myristoylated alanine rich protein kinase C substrate Homo sapiens