Title : MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer.

Pub. Date : 2010 Dec

PMID : 19862647






1 Functional Relationships(s)
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1 These results suggest that EGFR inhibition by cetuximab may overcome this irinotecan resistance by abrogating drug efflux depending on MDR1 3435 polymorphism. Irinotecan epidermal growth factor receptor Homo sapiens