Title : Development of a high-performance liquid chromatographic-mass spectrometric method for the determination of cellular levels of the tyrosine kinase inhibitors lapatinib and dasatinib.

Pub. Date : 2009 Dec 1

PMID : 19854117






2 Functional Relationships(s)
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1 Additionally, over-expression of the membrane protein drug transporter, P-glycoprotein (P-gp) a common cancer drug resistance mechanism, greatly reduces the cellular accumulation of dasatinib but not of lapatinib. Lapatinib ATP binding cassette subfamily B member 1 Homo sapiens
2 Additionally, over-expression of the membrane protein drug transporter, P-glycoprotein (P-gp) a common cancer drug resistance mechanism, greatly reduces the cellular accumulation of dasatinib but not of lapatinib. Lapatinib ATP binding cassette subfamily B member 1 Homo sapiens