Pub. Date : 2010 Jan 21
PMID : 19838217
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy. | Oxaliplatin | DNA polymerase beta | Homo sapiens |
| 2 | DNA damage induced by oxaliplatin treatment of HCT116 and HT29 colon cancer cells was observed to be associated with the stabilization of Pol beta protein on chromatin. | Oxaliplatin | DNA polymerase beta | Homo sapiens |
| 3 | In comparison with HCT116 colon cancer cells, isogenic oxaliplatin-resistant (HCT-OR) cells were found to have higher constitutive levels of Pol beta protein, faster in vitro repair of a DNA substrate containing a single nucleotide gap and faster repair of 1,2-GG oxaliplatin adduct levels in cells. | Oxaliplatin | DNA polymerase beta | Homo sapiens |
| 4 | In HCT-OR cells, small interfering RNA knockdown of Pol beta delayed the repair of oxaliplatin-induced DNA damage. | Oxaliplatin | DNA polymerase beta | Homo sapiens |
| 5 | In a different model system, Pol beta-deficient fibroblasts were less able to repair 1,2-GG oxaliplatin adducts and were hypersensitive to oxaliplatin treatment compared with isogenic Pol beta-expressing cells. | Oxaliplatin | DNA polymerase beta | Homo sapiens |
| 6 | In a different model system, Pol beta-deficient fibroblasts were less able to repair 1,2-GG oxaliplatin adducts and were hypersensitive to oxaliplatin treatment compared with isogenic Pol beta-expressing cells. | Oxaliplatin | DNA polymerase beta | Homo sapiens |
| 7 | These data provide the first link between oxaliplatin sensitivity and DNA repair involving Pol beta. | Oxaliplatin | DNA polymerase beta | Homo sapiens |
| 8 | They demonstrate that Pol beta modulates the sensitivity of cells to oxaliplatin treatment. | Oxaliplatin | DNA polymerase beta | Homo sapiens |