Pub. Date : 2009 Dec 11
PMID : 19833721
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and reactive oxygen species production in caveolin-enriched microdomains of the endothelium. | Reactive Oxygen Species | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Silencing caveolin-1 (which blocks CEM formation) and/or c-Abl expression with small interference RNA inhibited hyperoxia-mediated tyrosine phosphorylation and association of dynamin 2 with p47(phox) and ROS production. | Reactive Oxygen Species | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | These results suggest that hyperoxia induces c-Abl-mediated dynamin 2 phosphorylation required for recruitment of p47(phox) to CEMs and subsequent ROS production in lung endothelium. | Reactive Oxygen Species | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |