Title : Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential.

Pub. Date : 2010 Feb

PMID : 19831728






1 Functional Relationships(s)
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1 In the present review, we will discuss i) how bilirubin reduces its circulating levels by activating AhR in the liver; ii) how bile acids modulate their hepatic glucuronidation via PXR- and FXR-dependent processes in enterohepatic tissues; and iii) how androgens inhibit their cellular metabolism in prostate cancer cells through an AR-dependent mechanism. Bilirubin aryl hydrocarbon receptor Homo sapiens