Pub. Date : 2010 Feb 15
PMID : 19830782
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 2 | Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 3 | Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 4 | Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 5 | Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 6 | As PSMA is able to hydrolyze polyglutamated folates, and cancer cells proliferate directly in response to available folate, we examined if expression of human PSMA in PC-3 cells confers a proliferative advantage in a microenvironment with physiologically relevant folate levels. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 7 | Folic acid was tested for its ability to competitively inhibit the enzymatic activity of PSMA. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 8 | In media containing physiologic levels of folate, PSMA expression increased folic acid uptake approximately twofold over non-expressing cells. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 9 | In media containing physiologic levels of folate, PSMA expression increased folic acid uptake approximately twofold over non-expressing cells. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 10 | Folic acid was able to inhibit hydrolysis of N-[4-(phenylazo)-benzoyl]-glutamyl-gamma-glutamic acid (PABGgG) by PSMA in a competitive inhibition assay. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 11 | CONCLUSION: These findings implicate PSMA in both the metabolism of polyglutamated folates, and in the uptake of monoglutamated folates. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 12 | CONCLUSION: These findings implicate PSMA in both the metabolism of polyglutamated folates, and in the uptake of monoglutamated folates. | Folic Acid | folate hydrolase 1 | Homo sapiens |