PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19830782-0 2010 Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. Folic Acid 72-78 folate hydrolase 1 Homo sapiens 50-54 19830782-0 2010 Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. Folic Acid 179-185 folate hydrolase 1 Homo sapiens 50-54 19830782-0 2010 Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. Folic Acid 179-185 folate hydrolase 1 Homo sapiens 134-138 19830782-0 2010 Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. Folic Acid 187-197 folate hydrolase 1 Homo sapiens 50-54 19830782-0 2010 Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. Folic Acid 187-197 folate hydrolase 1 Homo sapiens 134-138 19830782-3 2010 As PSMA is able to hydrolyze polyglutamated folates, and cancer cells proliferate directly in response to available folate, we examined if expression of human PSMA in PC-3 cells confers a proliferative advantage in a microenvironment with physiologically relevant folate levels. Folic Acid 44-50 folate hydrolase 1 Homo sapiens 3-7 19830782-5 2010 Folic acid was tested for its ability to competitively inhibit the enzymatic activity of PSMA. Folic Acid 0-10 folate hydrolase 1 Homo sapiens 89-93 19830782-7 2010 In media containing physiologic levels of folate, PSMA expression increased folic acid uptake approximately twofold over non-expressing cells. Folic Acid 42-48 folate hydrolase 1 Homo sapiens 50-54 19830782-7 2010 In media containing physiologic levels of folate, PSMA expression increased folic acid uptake approximately twofold over non-expressing cells. Folic Acid 76-86 folate hydrolase 1 Homo sapiens 50-54 19830782-8 2010 Folic acid was able to inhibit hydrolysis of N-[4-(phenylazo)-benzoyl]-glutamyl-gamma-glutamic acid (PABGgG) by PSMA in a competitive inhibition assay. Folic Acid 0-10 folate hydrolase 1 Homo sapiens 112-116 19830782-9 2010 CONCLUSION: These findings implicate PSMA in both the metabolism of polyglutamated folates, and in the uptake of monoglutamated folates. Folic Acid 83-90 folate hydrolase 1 Homo sapiens 37-41 19830782-9 2010 CONCLUSION: These findings implicate PSMA in both the metabolism of polyglutamated folates, and in the uptake of monoglutamated folates. Folic Acid 128-135 folate hydrolase 1 Homo sapiens 37-41