Title : Inhibition of azoxymethane-induced colorectal cancer by CP-31398, a TP53 modulator, alone or in combination with low doses of celecoxib in male F344 rats.

Pub. Date : 2009 Oct 15

PMID : 19826045






1 Functional Relationships(s)
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1 Rats that were fed the high-dose CP-31398 or a combination of low-dose CP-31398 and celecoxib showed considerable enhancement of p53 and p21(WAF1/CIP) expression, apoptosis, and reduced tumor cell proliferation in colonic tumors. Celecoxib KRAS proto-oncogene, GTPase Rattus norvegicus