Title : NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance.

Pub. Date : 2009 Oct 12

PMID : 19823672






1 Functional Relationships(s)
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1 Coincubating cells with a sublethal concentration of paclitaxel in combination with each of 2,000 small molecule compounds from the National Cancer Institute Diversity Set Library, we identified a previously uncharacterized molecule, NSC23925, that inhibits Pgp1 and reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR. Paclitaxel ATP binding cassette subfamily C member 1 Homo sapiens