Title : Mutual priming effects of GHRH and arginine on GH secretion: informative procedure for evaluating GH secretory dynamics.

Pub. Date : 1990 Aug

PMID : 1982090






10 Functional Relationships(s)
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1 In 4 normal subjects, a bolus injection of 50 micrograms of GHRH followed by 0.5 g/kg Arg infusion after 90 min evoked two GH peaks and the priming of the GHRH potentiated Arg-induced GH peak by 88% of that by Arg alone. Arginine growth hormone releasing hormone Homo sapiens
2 In 4 normal subjects, a bolus injection of 50 micrograms of GHRH followed by 0.5 g/kg Arg infusion after 90 min evoked two GH peaks and the priming of the GHRH potentiated Arg-induced GH peak by 88% of that by Arg alone. Arginine growth hormone releasing hormone Homo sapiens
3 In 4 normal subjects, a bolus injection of 50 micrograms of GHRH followed by 0.5 g/kg Arg infusion after 90 min evoked two GH peaks and the priming of the GHRH potentiated Arg-induced GH peak by 88% of that by Arg alone. Arginine growth hormone releasing hormone Homo sapiens
4 In 4 normal subjects, a bolus injection of 50 micrograms of GHRH followed by 0.5 g/kg Arg infusion after 90 min evoked two GH peaks and the priming of the GHRH potentiated Arg-induced GH peak by 88% of that by Arg alone. Arginine growth hormone releasing hormone Homo sapiens
5 In 4 normal subjects, a bolus injection of 50 micrograms of GHRH followed by 0.5 g/kg Arg infusion after 90 min evoked two GH peaks and the priming of the GHRH potentiated Arg-induced GH peak by 88% of that by Arg alone. Arginine growth hormone releasing hormone Homo sapiens
6 In contrast, Arg pretreatment suppressed the GHRH-induced GH peak to a level of 15%. Arginine growth hormone releasing hormone Homo sapiens
7 In 4 other normal subjects, the effect of endogenous GH fluctuation on the GHRH-Arg test was examined in the morning, afternoon and evening. Arginine growth hormone releasing hormone Homo sapiens
8 The GHRH-Arg test is therefore able to evaluate GH secretory dynamics through two major mechanisms, GHRH stimulation and SRIH inhibition in a single procedure, reducing the incidence of false negative GH response to Arg. Arginine growth hormone releasing hormone Homo sapiens
9 The GHRH-Arg test is therefore able to evaluate GH secretory dynamics through two major mechanisms, GHRH stimulation and SRIH inhibition in a single procedure, reducing the incidence of false negative GH response to Arg. Arginine growth hormone releasing hormone Homo sapiens
10 The GHRH-Arg test is therefore able to evaluate GH secretory dynamics through two major mechanisms, GHRH stimulation and SRIH inhibition in a single procedure, reducing the incidence of false negative GH response to Arg. Arginine growth hormone releasing hormone Homo sapiens