Title : Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage.

Pub. Date : 2010 Jan

PMID : 19812371






1 Functional Relationships(s)
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1 In U87MG (p53wt) cells cotreated with TPT and pifithrin-alpha, or transfected with p53-siRNA, caspase-2 and Bid were significantly cleaved and XIAP/survivin was degraded. pifithrin BH3 interacting domain death agonist Homo sapiens