Title : Increase in the level of P-glycoprotein mRNA expression in multidrug-resistant K562 cell lines treated with sodium butyrate is not accompanied with erythroid differentiation.

Pub. Date : 1990 Dec

PMID : 1980493






4 Functional Relationships(s)
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1 Increase in the level of P-glycoprotein mRNA expression in multidrug-resistant K562 cell lines treated with sodium butyrate is not accompanied with erythroid differentiation. Butyric Acid ATP binding cassette subfamily B member 1 Homo sapiens
2 We examined the effect of hemin, sodium butyrate and mitomycin C on levels of P-glycoprotein mRNA in human myelogenous K562 cells by northern blot analysis. Butyric Acid ATP binding cassette subfamily B member 1 Homo sapiens
3 After treatment with sodium butyrate a dose-dependent increase of P-glycoprotein mRNA expression was observed in the adriamycin-resistant K562 and vincristine-resistant K562 lines. Butyric Acid ATP binding cassette subfamily B member 1 Homo sapiens
4 With 10 mM sodium butyrate, the level of P-glycoprotein mRNA reached 20 times that of control adriamycin-resistant K562 and with 30 mM sodium butyrate, it exceeded 5 times that of control vincristine-resistant K562. Butyric Acid ATP binding cassette subfamily B member 1 Homo sapiens