Title : D1 priming enhances both D1- and D2-mediated rotational behavior and striatal Fos expression in 6-hydroxydopamine lesioned rats.

Pub. Date : 2010 Jan

PMID : 19800912






3 Functional Relationships(s)
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1 D1 priming enhances both D1- and D2-mediated rotational behavior and striatal Fos expression in 6-hydroxydopamine lesioned rats. Oxidopamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 6-OHDA rats challenged with SKF38393 (1mg/kg) showed no contralateral rotational behavior, but robust striatal Fos expression in D1-primed animals. Oxidopamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 These data suggest that D1- or D2-priming enhances rotational behavior following challenge with D1 or D2 agonist, but only D1-priming enhances D1- and D2-mediated striatal Fos expression in 6-OHDA rats. Oxidopamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus