Pub. Date : 2010 Jan
PMID : 19794412
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: a Go-DARTS study. | Sulfonylurea Compounds | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | Sulfonylureas are metabolized mainly by the cytochrome p450 2C9 (CYP2C9) enzyme. | Sulfonylurea Compounds | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | Sulfonylureas are metabolized mainly by the cytochrome p450 2C9 (CYP2C9) enzyme. | Sulfonylurea Compounds | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 4 | In conclusion, CYP2C9 loss-of-function alleles are associated with greater response to sulfonylureas and decreased failure of therapy consistent with the pharmacokinetic role of CYP2C9. | Sulfonylurea Compounds | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |