Title : Chronic methionine sulfoximine administration reduces synaptosomal aspartate and glutamate in rat striatum.

Pub. Date : 1990 Jul 31

PMID : 1978267






1 Functional Relationships(s)
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1 Methionine sulfoxime (MS) is an inhibitor of glutamine synthetase, an astroglial enzyme believed to be involved in the maintenance of glutamine, a major precursor for neurotransmitter pools of the excitatory amino acids aspartate and glutamate in striatal afferent axon terminals. Glutamic Acid glutamate-ammonia ligase Rattus norvegicus