Title : Mechanisms involved in ultrafine carbon black-induced release of IL-6 from primary rat epithelial lung cells.

Pub. Date : 2010 Feb

PMID : 19782127






1 Functional Relationships(s)
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1 Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta. Curcumin mitogen-activated protein kinase 8 Rattus norvegicus