Title : Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS.

Pub. Date : 2009 Dec

PMID : 19781786






2 Functional Relationships(s)
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1 In contrast to mice injected with LPS, mice exposed to hyaluronan prior to LPS had greatly decreased serum IL-6 and TNFalpha and were protected from symptoms of sepsis. Hyaluronic Acid interleukin 6 Mus musculus
2 Consistent with our findings in vivo, addition of hyaluronan to macrophages before LPS exposure significantly decreased the release of IL-6 and TNFalpha and this effect was not seen in macrophages from Cd44(-/-) mice. Hyaluronic Acid interleukin 6 Mus musculus