Title : Sesquiterpene lactone parthenolide markedly enhances sensitivity of human A549 cells to low-dose oxaliplatin via inhibition of NF-kappaB activation and induction of apoptosis.

Pub. Date : 2010 Feb

PMID : 19774508






3 Functional Relationships(s)
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1 Sesquiterpene lactone parthenolide markedly enhances sensitivity of human A549 cells to low-dose oxaliplatin via inhibition of NF-kappaB activation and induction of apoptosis. parthenolide nuclear factor kappa B subunit 1 Homo sapiens
2 Thus, this study was performed to explore the effect of parthenolide, a natural NF-kappaB inhibitor, on human lung cancer A549 cells treated with low-dose oxaliplatin, as well as to determine the potential mechanisms involved. parthenolide nuclear factor kappa B subunit 1 Homo sapiens
3 These findings indicate that parthenolide could markedly enhance sensitivity of A549 cells to low-dose oxaliplatin by inhibiting NF-kappaB activation and inducing apoptosis. parthenolide nuclear factor kappa B subunit 1 Homo sapiens