Title : alpha-Lactalbumin, engineered to be nonnative and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding.

Pub. Date : 2009 Dec 18

PMID : 19766653






1 Functional Relationships(s)
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1 To this end, we utilize a recombinant variant of human alpha-lactalbumin in which all eight cysteine residues are substituted for alanines (rHLA(all-Ala)), rendering the protein nonnative and biologically inactive under all conditions. Cysteine lactalbumin alpha Homo sapiens