Title : [Interaction of glucocorticoids and the Sonic Hedgehog pathway during brain development].

Pub. Date : 2009 Aug-Sep

PMID : 19765385






1 Functional Relationships(s)
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1 Shh is a crucial regulator of brain development and neural stem/progenitor cells, and GCs suppress Shh-induced proliferation of cerebellar progenitor cells ; Shh acts through the induction of the enzyme 11betaHSD2, which inactivates the GCs corticosterone and prednisolone, but not dexamethasone. Corticosterone hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens