Title : Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.

Pub. Date : 1990 Sep

PMID : 1976255






1 Functional Relationships(s)
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1 Expression of the mutant P-glycoprotein also resulted in significantly increased resistance to epipodophyllotoxin and decreased resistance to vincristine and actinomycin D; smaller changes in resistance were observed for several other drugs. Podophyllotoxin ATP binding cassette subfamily B member 1 Homo sapiens