Title : Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis.

Pub. Date : 2009 Dec

PMID : 19755915






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Pretreatment of the rats with atorvastatin (10 mg/kg, orally) 48, 24, and 2 hours before induction of sepsis preserved acetylcholine-induced relaxation, eNOS mRNA expression, acetylcholine-stimulated NO release, and attenuated increase in the inducible NO synthase mRNA expression and basal NO production in the aorta. Atorvastatin nitric oxide synthase 2 Rattus norvegicus