Title : Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development.

Pub. Date : 2009

PMID : 19754423






1 Functional Relationships(s)
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1 The recently published crystal structure of CYP1A2 in complex with alpha-naphthoflavone has showed a rather compact active site with a relatively small volume of the cavity of 375 A(3), which is 44.2% and 49.3% larger than that of CYP2A6 (260 A(3)) and CYP2E1 (190 A(3)), respectively. alpha-naphthoflavone cytochrome P450 family 1 subfamily A member 2 Homo sapiens