Title : Uncoupling protein 1 inhibition by purine nucleotides is under the control of the endogenous ubiquinone redox state.

Pub. Date : 2009 Nov 11

PMID : 19747168






3 Functional Relationships(s)
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1 Uncoupling protein 1 inhibition by purine nucleotides is under the control of the endogenous ubiquinone redox state. Purine Nucleotides uncoupling protein 1 Rattus norvegicus
2 Our studies of the membranous ubiquinone reduction level in mitochondria demonstrate that activation of UCP1 leads to a purine nucleotide-sensitive decrease in the ubiquinone redox state. Purine Nucleotides uncoupling protein 1 Rattus norvegicus
3 The ubiquinone redox state-dependent alleviation of UCP1 inhibition by the purine nucleotide was observed at a high ubiquinone reduction level, when it exceeded 85-88%. Purine Nucleotides uncoupling protein 1 Rattus norvegicus