Title : Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.

Pub. Date : 2009 Sep 11

PMID : 19745154






2 Functional Relationships(s)
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1 Through structural analysis of DOCK9-Cdc42 complexes, we identify a nucleotide sensor within the alpha10 helix of the DHR2 domain that contributes to release of guanine diphosphate (GDP) and then to discharge of the activated GTP-bound Cdc42. Guanosine Diphosphate cell division cycle 42 Homo sapiens
2 Through structural analysis of DOCK9-Cdc42 complexes, we identify a nucleotide sensor within the alpha10 helix of the DHR2 domain that contributes to release of guanine diphosphate (GDP) and then to discharge of the activated GTP-bound Cdc42. Guanosine Diphosphate cell division cycle 42 Homo sapiens