Title : Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.

Pub. Date : 2009 Sep 9

PMID : 19741129






1 Functional Relationships(s)
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1 We further demonstrate that statins block calcium-dependent calpain activation, resulting in complete suppression of protein truncation events on multiple calpain substrates that are involved in neuronal death including CDK5 coactivator p35 cleavage to p25, GSK3 and beta-catenin. Calcium cyclin dependent kinase 5 Homo sapiens