Pub. Date : 2009 Oct
PMID : 19725919
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chemotherapeutic drugs that intercalate into DNA and inhibit topoisomerase II such as Doxorubicin, Daunorubicin and Mitoxantrone stimulate NF-kappaB DNA binding and transcriptional activity prior to induction of cell death. | Daunorubicin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Importantly, specific inhibition of drug-induced NF-kappaB activation by IkappaBalpha-SR or RNA interference against p65 significantly reduces apoptosis upon treatment with Doxorubicin, Daunorubicin or Mitoxantrone. | Daunorubicin | nuclear factor kappa B subunit 1 | Homo sapiens |