Title : N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway.

Pub. Date : 2010 Jan

PMID : 19722195






2 Functional Relationships(s)
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1 Furthermore, the PERK-ATF4 pathway, which also induces the expression of CHOP, was activated in NAC-treated cells. Acetylcysteine DNA damage inducible transcript 3 Homo sapiens
2 The role of the ER stress pathway was further confirmed through the small interfering RNA (siRNA)-mediated knockdown of CHOP, which attenuated NAC and PEN-induced apoptosis. Acetylcysteine DNA damage inducible transcript 3 Homo sapiens