Pub. Date : 2009 Sep
PMID : 19721393
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
2 | Preventing de novo ceramide synthesis abolished the antagonistic effect of palmitate toward the Akt/ eNOS pathway. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
3 | CONCLUSIONS: Taken together, we have demonstrated that palmitic acid induces accumulation of ceramide, which appears to mediate palmitic acid"s inhibitory effects on the Akt/eNOS pathway, leading to a significant decrease in NO generation. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
4 | Therefore, ceramide is a necessary and sufficient intermediate mediating the inhibition of the AKT/eNOS signaling pathway by palmitate in endothelial cells. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |