Title : Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells.

Pub. Date : 2009 Sep

PMID : 19721393






4 Functional Relationships(s)
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1 Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells. Ceramides AKT serine/threonine kinase 1 Homo sapiens
2 Preventing de novo ceramide synthesis abolished the antagonistic effect of palmitate toward the Akt/ eNOS pathway. Ceramides AKT serine/threonine kinase 1 Homo sapiens
3 CONCLUSIONS: Taken together, we have demonstrated that palmitic acid induces accumulation of ceramide, which appears to mediate palmitic acid"s inhibitory effects on the Akt/eNOS pathway, leading to a significant decrease in NO generation. Ceramides AKT serine/threonine kinase 1 Homo sapiens
4 Therefore, ceramide is a necessary and sufficient intermediate mediating the inhibition of the AKT/eNOS signaling pathway by palmitate in endothelial cells. Ceramides AKT serine/threonine kinase 1 Homo sapiens