Title : Expression of cyclooxygenase-1/-2, microsomal prostaglandin-E synthase-1 and E-prostanoid receptor 2 and regulation of inflammatory mediators by PGE(2) in the amoeboid microglia in hypoxic postnatal rats and murine BV-2 cells.

Pub. Date : 2009 Dec 15

PMID : 19712723






2 Functional Relationships(s)
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1 Interestingly, treatment with EP2 antagonist AH-6809 resulted in suppression of hypoxia induced EP2, IL-1beta and iNOS mRNA and protein expression, TNF-alpha protein expression and intracellular cAMP level in BV-2 cells. Cyclic AMP prostaglandin E receptor 2 (subtype EP2) Mus musculus
2 It is suggested that PGE(2) may regulate above inflammatory mediators in the activated microglia via EP2-cAMP signaling pathway in hypoxic conditions. Cyclic AMP prostaglandin E receptor 2 (subtype EP2) Mus musculus