Pub. Date : 2009 Aug 25
PMID : 19706164
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy. | Celecoxib | tumor protein p53 | Homo sapiens |
| 2 | We investigated whether the anti-glioblastoma responses of celecoxib were p53-dependent, and whether celecoxib induced DNA damage leading to p53-dependent G1 cell cycle arrest, followed by autophagy or apoptosis. | Celecoxib | tumor protein p53 | Homo sapiens |
| 3 | Inhibition of functional p53 in glioblastoma cells significantly reduced the anti-proliferative effect of celecoxib. | Celecoxib | tumor protein p53 | Homo sapiens |
| 4 | In U87MG cells, celecoxib (8 and 30 muM) significantly induced DNA damage and inhibited DNA synthesis, corresponding with p53 activation. | Celecoxib | tumor protein p53 | Homo sapiens |
| 5 | CONCLUSION: Our findings reveal that p53 increases human glioblastoma sensitivity to celecoxib. | Celecoxib | tumor protein p53 | Homo sapiens |
| 6 | Celecoxib inhibits glioblastoma cell viability by induction of DNA damage, leading to p53-dependent G1 cell cycle arrest and p53-dependent autophagy, but not apoptosis. | Celecoxib | tumor protein p53 | Homo sapiens |
| 7 | Celecoxib inhibits glioblastoma cell viability by induction of DNA damage, leading to p53-dependent G1 cell cycle arrest and p53-dependent autophagy, but not apoptosis. | Celecoxib | tumor protein p53 | Homo sapiens |