Pub. Date : 2010 Mar
PMID : 19695284
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The NMDAR contains a D-serine/glycine site on the NR1 subunit that may be a promising therapeutic target for psychiatric illness. | Glycine | glutamate receptor, ionotropic, NMDA1 (zeta 1) | Mus musculus |
| 2 | The NMDAR contains a D-serine/glycine site on the NR1 subunit that may be a promising therapeutic target for psychiatric illness. | Glycine | glutamate receptor, ionotropic, NMDA1 (zeta 1) | Mus musculus |
| 3 | This review outlines the complex regulation of endogenous NMDAR D-serine/glycine site agonists and explores their contribution to schizophrenia pathogenesis and their potential clinical utility. | Glycine | glutamate receptor, ionotropic, NMDA1 (zeta 1) | Mus musculus |
| 4 | Genetic studies have associated genes influencing NMDAR D-serine/glycine site activation with an increased susceptibility to schizophrenia. | Glycine | glutamate receptor, ionotropic, NMDA1 (zeta 1) | Mus musculus |
| 5 | Genetically modified mice with aberrant NMDAR D-serine/glycine site function model certain features of the negative and cognitive symptoms of schizophrenia, and similar behavioral abnormalities have been observed in other candidate genes models. | Glycine | glutamate receptor, ionotropic, NMDA1 (zeta 1) | Mus musculus |
| 6 | Compounds that directly activate the NMDAR D-serine/glycine site or inhibit glycine transport have demonstrated beneficial effects in preclinical models and clinical trials. | Glycine | glutamate receptor, ionotropic, NMDA1 (zeta 1) | Mus musculus |