Title : Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure.

Pub. Date : 2010 Mar

PMID : 19694794






1 Functional Relationships(s)
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1 RESULTS: Coadministration of muscimol and baclofen exerted neuroprotection against neuron death induced by KA; inhibited the increased assembly of the GluR6-PSD-95-MLK3 module induced by KA; and suppressed the activation of MLK3, MKK7, and JNK3. Baclofen discs large MAGUK scaffold protein 4 Rattus norvegicus