Title : Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment.

Pub. Date : 2009 Sep 3

PMID : 19693011






1 Functional Relationships(s)
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1 Overexpression of ERBB2 rescues the ATP deficiency by restoring glucose uptake through stabilization of EGFR and phosphatidylinositol-3-OH kinase (PI(3)K) activation, and this rescue is dependent on glucose-stimulated flux through the antioxidant-generating pentose phosphate pathway. Glucose epidermal growth factor receptor Homo sapiens