Title : Phosphodiesterase inhibition increases CREB phosphorylation and restores orientation selectivity in a model of fetal alcohol spectrum disorders.

Pub. Date : 2009 Aug 14

PMID : 19680548






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 METHODOLOGY/PRINCIPAL FINDINGS: Here we show that the primary visual cortex of ferrets exposed to alcohol during the third trimester equivalent of human gestation have decreased CREB phosphorylation and poor orientation selectivity revealed by western blotting, optical imaging of intrinsic signals and single-unit extracellular recording techniques. Alcohols cAMP responsive element binding protein 1 Homo sapiens
2 Treating animals several days after the period of alcohol exposure with a phosphodiesterase type 1 inhibitor (Vinpocetine) increased CREB phosphorylation and restored orientation selectivity columns and neuronal orientation tuning. Alcohols cAMP responsive element binding protein 1 Homo sapiens