Title : SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation.

Pub. Date : 2009 Sep 16

PMID : 19680224






1 Functional Relationships(s)
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1 The de-SUMOylating activity of SENP3 is required for ROS-induced increase of HIF-1 transactivation, but the true substrate of SENP3 is the co-activator of HIF-1 alpha, p300, rather than HIF-1 alpha itself. Reactive Oxygen Species E1A binding protein p300 Mus musculus