Title : Nicotine enhances skin necrosis and expression of inflammatory mediators in a rat pressure ulcer model.

Pub. Date : 2009 Nov

PMID : 19673871






2 Functional Relationships(s)
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Protein Name
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1 I/R treatment increased mRNA levels of COX-2, IL-1beta, IL-6 and iNOS, which were further augmented by nicotine in a dose-dependent manner. Nicotine prostaglandin-endoperoxide synthase 2 Rattus norvegicus
2 Correspondingly, nicotine (0.35 mg kg(-1) daily) markedly enhanced the protein expression of COX-2 and iNOS. Nicotine prostaglandin-endoperoxide synthase 2 Rattus norvegicus