Title : John Daly's compound, epibatidine, facilitates identification of nicotinic receptor subtypes.

Pub. Date : 2010 Jan

PMID : 19672723






6 Functional Relationships(s)
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1 The diversity of nicotinic acetylcholine receptor (nAChR) subtypes was explored by measuring the effects of gene deletion and pharmacological diversity of epibatidine binding sites in mouse brain. epibatidine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 The diversity of nicotinic acetylcholine receptor (nAChR) subtypes was explored by measuring the effects of gene deletion and pharmacological diversity of epibatidine binding sites in mouse brain. epibatidine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 In agreement with general belief, the alpha4beta2*-nAChR and alpha7-nAChR subtypes are major components of the epibatidine binding sites. epibatidine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
4 In agreement with general belief, the alpha4beta2*-nAChR and alpha7-nAChR subtypes are major components of the epibatidine binding sites. epibatidine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
5 alpha4beta2*-nAChR sites account for approximately 70% of total high- and low-affinity epibatidine binding sites, while alpha7-nAChR accounts for 16% of the total sites all of which have lower affinity for epibatidine. epibatidine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
6 alpha4beta2*-nAChR sites account for approximately 70% of total high- and low-affinity epibatidine binding sites, while alpha7-nAChR accounts for 16% of the total sites all of which have lower affinity for epibatidine. epibatidine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus