Title : Tumor necrosis factor alpha 'primes' the platelet-activating factor-induced superoxide production by human neutrophils: possible involvement of G proteins.

Pub. Date : 1990

PMID : 1966810






8 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Tumor necrosis factor alpha "primes" the platelet-activating factor-induced superoxide production by human neutrophils: possible involvement of G proteins. Superoxides tumor necrosis factor Homo sapiens
2 We were interested to ascertain whether superoxide generation by human PMN could be amplified by PAF following initial stimulation with tumor necrosis factor (TNF) and the effect of cholera and pertussis toxin on this process. Superoxides tumor necrosis factor Homo sapiens
3 We were interested to ascertain whether superoxide generation by human PMN could be amplified by PAF following initial stimulation with tumor necrosis factor (TNF) and the effect of cholera and pertussis toxin on this process. Superoxides tumor necrosis factor Homo sapiens
4 The PAF antagonists also decreased by 25% the superoxide production elicited solely by TNF, indicating that TNF-induced superoxide generation is partially mediated by a mechanism involving endogenous PAF. Superoxides tumor necrosis factor Homo sapiens
5 The PAF antagonists also decreased by 25% the superoxide production elicited solely by TNF, indicating that TNF-induced superoxide generation is partially mediated by a mechanism involving endogenous PAF. Superoxides tumor necrosis factor Homo sapiens
6 The PAF antagonists also decreased by 25% the superoxide production elicited solely by TNF, indicating that TNF-induced superoxide generation is partially mediated by a mechanism involving endogenous PAF. Superoxides tumor necrosis factor Homo sapiens
7 The PAF antagonists also decreased by 25% the superoxide production elicited solely by TNF, indicating that TNF-induced superoxide generation is partially mediated by a mechanism involving endogenous PAF. Superoxides tumor necrosis factor Homo sapiens
8 Pretreatment of the PMN with pertussis or cholera toxin reduced the amplification of superoxide production induced by PAF in TNF-stimulated PMN, implicating pertussis and cholera toxin-sensitive G-proteins in the amplification process. Superoxides tumor necrosis factor Homo sapiens