PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1966810-0 1990 Tumor necrosis factor alpha "primes" the platelet-activating factor-induced superoxide production by human neutrophils: possible involvement of G proteins. Superoxides 76-86 tumor necrosis factor Homo sapiens 0-27 1966810-2 1990 We were interested to ascertain whether superoxide generation by human PMN could be amplified by PAF following initial stimulation with tumor necrosis factor (TNF) and the effect of cholera and pertussis toxin on this process. Superoxides 40-50 tumor necrosis factor Homo sapiens 136-157 1966810-2 1990 We were interested to ascertain whether superoxide generation by human PMN could be amplified by PAF following initial stimulation with tumor necrosis factor (TNF) and the effect of cholera and pertussis toxin on this process. Superoxides 40-50 tumor necrosis factor Homo sapiens 159-162 1966810-5 1990 The PAF antagonists also decreased by 25% the superoxide production elicited solely by TNF, indicating that TNF-induced superoxide generation is partially mediated by a mechanism involving endogenous PAF. Superoxides 46-56 tumor necrosis factor Homo sapiens 87-90 1966810-5 1990 The PAF antagonists also decreased by 25% the superoxide production elicited solely by TNF, indicating that TNF-induced superoxide generation is partially mediated by a mechanism involving endogenous PAF. Superoxides 46-56 tumor necrosis factor Homo sapiens 108-111 1966810-5 1990 The PAF antagonists also decreased by 25% the superoxide production elicited solely by TNF, indicating that TNF-induced superoxide generation is partially mediated by a mechanism involving endogenous PAF. Superoxides 120-130 tumor necrosis factor Homo sapiens 87-90 1966810-5 1990 The PAF antagonists also decreased by 25% the superoxide production elicited solely by TNF, indicating that TNF-induced superoxide generation is partially mediated by a mechanism involving endogenous PAF. Superoxides 120-130 tumor necrosis factor Homo sapiens 108-111 1966810-6 1990 Pretreatment of the PMN with pertussis or cholera toxin reduced the amplification of superoxide production induced by PAF in TNF-stimulated PMN, implicating pertussis and cholera toxin-sensitive G-proteins in the amplification process. Superoxides 85-95 tumor necrosis factor Homo sapiens 125-128