Title : 5-HT3 receptor antagonists attenuate dopamine-induced hyperactivity in the rat.

Pub. Date : 1990 Sep

PMID : 1966601






3 Functional Relationships(s)
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1 5-HT3 receptor antagonists attenuate dopamine-induced hyperactivity in the rat. Dopamine 5-hydroxytryptamine receptor 3A Rattus norvegicus
2 The 5-HT3 receptor antagonists, ICS205-930, granisetron and zacopride, at low doses, inhibited the hyperactivity caused by a 13 day mesolimbic dopamine infusion in the rat. Dopamine 5-hydroxytryptamine receptor 3A Rattus norvegicus
3 The ability of low doses of the 5-HT3 receptor antagonists to inhibit dopamine-induced behavioural changes is similar to the inhibitory profile of known antipsychotic agents. Dopamine 5-hydroxytryptamine receptor 3A Rattus norvegicus