Title : Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism.

Pub. Date : 2009 Oct 16

PMID : 19664596






1 Functional Relationships(s)
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1 Since NDI1 can functionally complement the complex I under the presence of metformin or rotenone, our results indicate that metformin induces down-regulation of G6pc expression through an inhibition of complex I and an activation of AMPK-independent mechanism. Rotenone NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae S288C