Pub. Date : 2009 Oct 16
PMID : 19664596
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism. | Metformin | glucose-6-phosphatase catalytic subunit 1 | Rattus norvegicus |
| 2 | Both metformin and rotenone, an inhibitor of respiratory chain complex I, suppressed glucose-6-phosphatase (G6pc), a rate limiting enzyme of liver glucose production, mRNA expression in a rat hepatoma cell line accompanied by a reduction of intracellular ATP concentration and an activation of AMP-activated protein kinase (AMPK). | Metformin | glucose-6-phosphatase catalytic subunit 1 | Rattus norvegicus |
| 3 | Both metformin and rotenone, an inhibitor of respiratory chain complex I, suppressed glucose-6-phosphatase (G6pc), a rate limiting enzyme of liver glucose production, mRNA expression in a rat hepatoma cell line accompanied by a reduction of intracellular ATP concentration and an activation of AMP-activated protein kinase (AMPK). | Metformin | glucose-6-phosphatase catalytic subunit 1 | Rattus norvegicus |
| 4 | Interestingly, in contrast to rotenone treatment, G6pc mRNA down-regulation was observed in the NDI1 expressing cells after metformin treatment. | Metformin | glucose-6-phosphatase catalytic subunit 1 | Rattus norvegicus |
| 5 | Since NDI1 can functionally complement the complex I under the presence of metformin or rotenone, our results indicate that metformin induces down-regulation of G6pc expression through an inhibition of complex I and an activation of AMPK-independent mechanism. | Metformin | glucose-6-phosphatase catalytic subunit 1 | Rattus norvegicus |