Pub. Date : 2009 Nov 1
PMID : 19661247
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MEASUREMENTS AND MAIN RESULTS: In a cell-free system, acrolein, in concentrations equal to those found in COPD sputum, directly adducted cysteine 319 in the MMP14 hemopexin-like domain and activated MMP14. | Acrolein | matrix metallopeptidase 14 (membrane-inserted) | Mus musculus |
| 2 | MEASUREMENTS AND MAIN RESULTS: In a cell-free system, acrolein, in concentrations equal to those found in COPD sputum, directly adducted cysteine 319 in the MMP14 hemopexin-like domain and activated MMP14. | Acrolein | matrix metallopeptidase 14 (membrane-inserted) | Mus musculus |
| 3 | In mouse lung, acrolein or tobacco smoke increased lung MMP14 activity and protein. | Acrolein | matrix metallopeptidase 14 (membrane-inserted) | Mus musculus |
| 4 | In cells, acrolein-induced MMP14 transcripts were inhibited by an epidermal growth factor receptor (EGFR) neutralizing antibody, EGFR kinase inhibitor, metalloproteinase inhibitor, or mitogen-activated protein kinase (MAPK) 3/2 or MAPK8 inhibitors, but not a MAPK14 inhibitor. | Acrolein | matrix metallopeptidase 14 (membrane-inserted) | Mus musculus |
| 5 | In acrolein-exposed mice or transgenic mice with lung-specific transforming growth factor-alpha (an EGFR ligand) expression, lung MMP14 and MUC5AC levels increased and these effects were inhibited by a EGFR inhibitor, erlotinib. | Acrolein | matrix metallopeptidase 14 (membrane-inserted) | Mus musculus |
| 6 | CONCLUSIONS: Taken together, these findings implicate acrolein-induced MMP14 expression and activity in mucin production in COPD. | Acrolein | matrix metallopeptidase 14 (membrane-inserted) | Mus musculus |